The papers in Volume II discuss the imperative of collective leadership and ASEAN centrality in light of the greater uncertainty in the global trading system and on regional security which have been underpinning ASEAN’s outward oriented strategy and development. It is suggested that ASEAN’s major Dialogue Partners in East Asia and the United States as well as ASEAN itself can be important contributors to strengthening collective leadership in East Asia and to enhancing ASEAN Centrality. The last paper in the volume presents ideas on how to strengthen ASEAN’s institutional ecosystem, which is important for ASEAN to be able to assert ASEAN centrality in an increasingly uncertain and changing regional environment.