In manufacturing veterinary vaccine, overall control is essential to ensure that consumers receive vaccine of high quality. Hazard operations in the manufacture of substances that may be necessary to save lives or to restore or preserve health cannot be permitted. The implementation of GMP Guidelines will ensure the quality of products in the market that will protect the public against risk of buying and using substandard products. It will also encourage all parties involved in the manufacture of animal vaccines to enhance and apply quality standards. To reliably achieve the quality objectives there must be comprehensively designed and correctly implemented systems of Quality Assurance incorporating GMP, Quality Control and Quality Risk Management. These systems should be fully documented and their effectiveness monitored.